Natural Selection on Synonymous and Nonsynonymous Mutations Shapes Patterns of Polymorphism in Populus tremula

Running title: Multi-locus polymorphism in Populus tremula Keywords: demography, linkage disequilibrium, nucleotide polymorphism, Populus tremula Multilocus patterns of nucleotide polymorphism and the demographic history of Populus tremula

I have studied nucleotide polymorphism and linkage disequilibrium using multilocus data from 77 fragments, with an average length of fragments 550 bp, in the deciduous tree Populus tremula (Salicaceae). The frequency spectrum across loci showed a modest excess of mutations segregating at low frequency and a marked excess of high frequency derived mutations at silent sites, relative to neutral e...

Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda.

We have investigated patterns of within-species polymorphism and between-species divergence for synonymous and nonsynonymous variants at a set of autosomal and X-linked loci of Drosophila miranda. D. pseudoobscura and D. affinis were used for the between-species comparisons. The results suggest the action of purifying selection on nonsynonymous, polymorphic variants. Among synonymous polymorphi...

Estimating selection on nonsynonymous mutations.

The distribution of mutational effects on fitness is of fundamental importance for many aspects of evolution. We develop two methods for characterizing the fitness effects of deleterious, nonsynonymous mutations, using polymorphism data from two related species. These methods also provide estimates of the proportion of amino acid substitutions that are selectively favorable, when combined with ...

Multilocus patterns of nucleotide polymorphism and the demographic history of Populus tremula.

I have studied nucleotide polymorphism and linkage disequilibrium using multilocus data from 77 fragments, with an average length of fragments of 550 bp, in the deciduous tree Populus tremula (Salicaceae). The frequency spectrum across loci showed a modest excess of mutations segregating at low frequency and a marked excess of high-frequency derived mutations at silent sites, relative to neutra...

Synonymous and Nonsynonymous Polymorphism vs. Divergence in Bacterial Genomes